HUMAN ANTIBODIES THAT BIND MULTIPLE IRTA FAMILY PROTEINS, AND USES THEREOF

摘要

The present disclosure provides isolated monoclonal antibodies that bind to multiple IRTA family proteins with high affinity, particularly human monoclonal antibodies. Preferred antibodies of the invention specifically bind an IRTA4 protein and at least one other IRTA family protein. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting IRTA proteins, as well as methods for treating various cancers, such as B cell lymphomas, using anti-IRTA antibodies of this disclosure.