发明名称 |
CONJUGATES OF HYDROXYALKYL STARCH AND A PROTEIN, PREPARED BY REDUCTIVE AMINATION |
摘要 |
The present invention relates to conjugates of hydroxyalkyl starch, preferably hydroxyethyl starch, and a protein, wherein these conjugates are formed by a reductive amination reaction between at least one aldehyde group or keto group or hemiacetal group of the hydroxyalkyl starch or of a derivative of the hydroxyalkyl starch, and at least one amino group of the protein, so that the hydroxyalkyl starch or the derivative thereof is covalently linked to the protein via an azomethine linkage or a amino linkage. The present invention also relates to the method of producing these conjugates and specific uses of the conjugates. |
申请公布号 |
EA010501(B1) |
申请公布日期 |
2008.10.30 |
申请号 |
EA20060001672 |
申请日期 |
2005.03.11 |
申请人 |
FRESENIUS KABI DEUTSCHLAND GMBH |
发明人 |
ZANDER NORBERT;EICHNER WOLFRAM;CONRADT HARALD;HACKET FRANK;LANGER KLAUS;ORLANDO MICHELE;FRANK RONALD |
分类号 |
C08B31/00;A61K38/18;A61K38/19;A61K38/20;A61K38/21;A61K38/38;A61K38/42;A61K38/44;A61K38/48;A61K38/55;A61K47/48;A61K51/06;A61K51/08;C07K14/00;C08B31/18 |
主分类号 |
C08B31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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