ANIONIC LIPID NANOSPHERE AND PREPARATION METHOD OF THE SAME

摘要

Disclosed is an anionic lipid nanosphere having negative surface charge and a method of its preparation, more particularly to a lipid nanosphere prepared by introducing polyethylene glycol (PEG) containing polymers on the surface of particles formed of anionic phospholipids to provide negative charge on the surface, thereby increasing encapsulation efficiency of a poorly water soluble drug in an aqueous medium, reducing toxicity of highly toxic drug against normal cells by encapsulating therewith, and increasing duration of circulation in the body, and a method of its preparation.