USES OF A MURINE MODEL OF HIV-1 INFECTION

摘要

The invention provides for a chimeric HIV-1 construct, EcoHIV, capable of replication in a rodent cell. The invention also provides a convenient and safe rodent model of HIV-1 infection and AIDS. A rodent model of HIV-1 infection is also provided which is useful for screening of candidate anti-viral drugs. Additionally, the invention provides for a method to test immunogenic compositions or pharmaceutical interventions effective in preventing infection, reducing viral load, or reducing disease symptoms in a subject.