发明名称 |
Anti-perp recombinant antibody |
摘要 |
An antibody which binds to a polypeptide encoded by human PERP (p53 apoptosis effector related to PMP-22) gene which is considered to be related to incidence of cancer or the like is desired. The present invention provides a gene recombinant antibody which has no consensus sequence of an N-linked sugar chain in a variable region, specifically recognizes three-dimensional structure of an extracellular region of a polypeptide encoded by the PERP gene and binds to the extracellular region. The antibody is useful for treatment of various diseases expressing a polypeptide encoded by the PERP gene.
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申请公布号 |
US2008267953(A1) |
申请公布日期 |
2008.10.30 |
申请号 |
US20060634209 |
申请日期 |
2006.12.06 |
申请人 |
KYOWA HAKKO KOGYO CO., LTD.;JAPAN AS REPRESENTED BY PRESIDENT OF NATIONAL CANCER CENTER |
发明人 |
OCHIAI ATSUSHI;HOSAKA EMI;NAKAMURA KAZUYASU;FURUYA AKIKO;OHKI YUJI |
分类号 |
A61K39/395;A61P35/00;C07K16/18;C12N5/16;C12N15/13;C12N15/85;C12P21/02 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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