CONJUGATE FOR THE SPECIFIC TARGETING OF ANTICANCER AGENTS TO CANCER CELLS AND PRODUCTION THEREOF

摘要

A conjugate is disclosed herein, wherein the conjugate comprises a ligand having the ability to bind to a receptor, wherein the receptor is overexpressed on a surface of a cancer cell, and an anticancer agent selectively toxic to cancer cells coupled to the ligand. The anticancer agent may be L-methioninase. Pharmaceutical compositions comprising the conjugate are also disclosed. A method of inducing tumor cell death in vivo is also disclosed and includes contacting a population of tumor cells in vivo with a therapeutically effective amount of the conjugate.