| 摘要 |
Immunogenic multivalent complexes comprise a receptor-binding domain of a two-domain adhesin antigen coupled with a carrier particle. Immunity-stimulating and adhesion-blocking agents; vaccines; and compositions comprise an immunogenic multivalent complex. Methods for identifying a two-domain adhesin antigen comprise selecting a sequence of a pilin from a chaperone/usher system; searching a protein and/or DNA sequence database with the pilin sequence; and identifying a sequence that aligns to the C-terminal portion of the pilin sequence and comprises an unmatched sequence of from about 140 to about 240 amino acid residues preceding the aligned region. |
