PULMONARY DELIVERY OF SPHERICAL INSULIN MICROPARTICLES
摘要
Compositions of spherical insulin particles having improved pulmonary application potentials and methods of forming and using these compositions are disclosed in the present application. In one clinical trial with 30 healthy male human subjects, no coughing was observed upon a single pulmonary administration of the spherical insulin particles at an insulin dose of 6.5 mg, nor during the 10-hour post dosing period.
申请公布号
WO2008130803(A2)
申请公布日期
2008.10.30
申请号
WO2008US59094
申请日期
2008.04.02
申请人
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE S.A.;BROWN, LARRY R.;MCGEEHAN, JOHN K.;YUANXI, QIN;RASHBA-STEP, JULIA;SCOTT, TERRENCE L.
发明人
BROWN, LARRY R.;MCGEEHAN, JOHN K.;YUANXI, QIN;RASHBA-STEP, JULIA;SCOTT, TERRENCE L.