IMPROVED PERSISTENTLY INFECTIVE SENDAI VIRUS VECTOR

摘要

Disclosed is a persistently infective virus vector produced by using a gene so modified as to encode an amino acid sequence having the substitution of an amino acid residue at position-1618 by a valine residue in the amino acid sequence for an L-protein of a persistently non-infective Sendai virus. Also disclosed is a non-transmissible, persistently infective virus vector produced by defecting or deleting at least one gene selected from M gene, F gene and HN gene. These virus vectors have no cytotoxicity, can achieve the sustained gene expression over a long period, is safe, and is therefore useful.