THERAPEUTIC PRO-ANTIBIOTIC AGENTS AND METHODS OF USE THEREOF

摘要

The present invention provides for therapies characterized in part by co-administration or combination of antibiotic agents with medicinal compositions comprising as the pro-antibiotic active ingredient either a compound represented by a formula [I] or a pharmaceutically acceptable composite thereof; [wherein X represents oxygen, sulfur, NH, or N-alkyl; R₁ and R₂ represent hydrogen, tetrazole, or alkyltetrazole, respectively (with the restriction that if R₁ is not hydrogen, R₂ must be, and vice versa); R₃ represents e.g., benzyl, phenyl optionally substituted, biphenyl, napthyl, N-phenylcarboxamido, etc.; R₄ represents e.g. carboxylic acid, or its alkyl esters, or a bioisosteric equivalent thereof, etc.; R₅ represents e.g. hydrogen, carboxylic acid, etc.]in particular, medicine which is useful as therapeutic and/or protective drugs for infectious and/or inflammatory diseases. Other relevant compounds are also provided.