SINGLE CHAIN FC, METHODS OF MAKING AND METHODS OF TREATMENT

摘要

The present invention relates generally to scFc molecules. The scFc molec ules comprise at least two Fc regions and at least one linker, and can be pr oduced in a variety of single chain configurations. The scFc molecules can f urther comprise at least one binding entity and/or at least one functional m olecule. Binding entities can be fused to the scFc molecule in a variety of configurations. The present invention also relates generally to methods for making such molecules and methods for their use. The scFc molecules provided herein can be recombinantly produced. Also provided are monovalent forms of the scFc molecules that have an equivalent or superior ADCC and/or CDC resp onse than do bivalent molecules targeting the same antigens. Provided herein are improved antigen binding compositions. Methods for using the scFc molec ules of the present inventions are provided