ZINC FINGER NUCLEASE FOR TARGETING THE HUMAN GLUCOCORTICOID RECEPTOR LOCUS
摘要
Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.
申请公布号
WO2008060510(A3)
申请公布日期
2008.10.30
申请号
WO2007US23745
申请日期
2007.11.13
申请人
SANGAMO BIOSCIENCES, INC.;CITY OF HOPE NATIONAL MEDICAL CENTER;REIK, ANDREAS;JENSEN, MICHAEL;HOLMES, MICHAEL C.;GREGORY, PHILIP D.;ANDO, DALE
发明人
REIK, ANDREAS;JENSEN, MICHAEL;HOLMES, MICHAEL C.;GREGORY, PHILIP D.;ANDO, DALE