The present invention relates to drug discovery methods, particularly methods for assaying compounds for activity as Aurora kinase inhibitors. This invention also relates to a pharmacophore describing compounds that are able to promote a conformational change in the protein AuroraB and whose binding constant for the two-step process is given as Ki*. Finally, this invention also relates to compounds having the features of the pharmacophore.
申请公布号
WO2008131103(A2)
申请公布日期
2008.10.30
申请号
WO2008US60635
申请日期
2008.04.17
申请人
VERTEX PHARMACEUTICALS INCORPORATED;BINCH, HAYLEY;WESTCOTT, JAMES;POLLARD, JOHN;MORTIMORE, MICHAEL;GOLEC, JULIAN;ROBINSON, DANIEL
发明人
BINCH, HAYLEY;WESTCOTT, JAMES;POLLARD, JOHN;MORTIMORE, MICHAEL;GOLEC, JULIAN;ROBINSON, DANIEL