| 摘要 |
<p>The invention identifies compounds which influence the activity of the ?-globin gene promoter and thus expression of the ?-globin gene. Such compounds are proposed to be useful in therapeutic protocols for treating hemoglobinopathy by induction of fetal hemoglobin production. The compound is selected from the group consisting of (i) a nucleoside analog; (ii) a nucleotide analog; or (iii) a compound selected from the group consisting of 4-acetoxyphenol, penicillic acid, hydroquinone, erysolin, diaziquone, aclacinomycin Al, thiotepa, 4-hydroxychalcone, melphalan, 6,3-dimethoxyflavone, 3-desmethyly-5-deshydroxyscleroin, isoliquiritigenin, pipobroman, hematoporphyrin dihydrochloride and quercetin and (iv) a combination of (i), (ii) and/or (iii) wit the proviso that the subject is not infected with HIV or has a condition characterised by polymerization of hemoglobin in the cells of the subject.</p> |
