OPTIMIZED NUCLEOTIDE SEQUENCES OF VB6-845 FOR EXPRESSION OF RECOMBINANT PROTEINS

摘要

An optimized nucleic acid sequence encoding the immunoconjugate VB6-845 i s described Modifications to the original VB6-845 include changes in the nuc leic acid sequence encoding the VH region, CH region, CL region, VL region, the furm linker and the bouganm toxin. The optimized VB6-845 displays improv ed recombinant protein expression over the original in an E.coli expression system.