This invention provides model systems for study of tumors. Model cells and model animals are prepared to mimic characteristics of natural clinical tumors. The tumor models can be contacted with putative modulators to screen for therapeutics and to help understand tumorigenic processes. Model animals can include model cells, closely correlated to the characteristics of clinical tumors, in an environment closely mimicking that of the tumors in patients. Thus, the animal models are highly representative for use in clinical and pharmacological studies.
申请公布号
WO2008109127(A3)
申请公布日期
2008.10.30
申请号
WO2008US02988
申请日期
2008.03.05
申请人
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES;MARUMOTO, TOMOTOSHI;VERMA, INDER;SODA, YASUSHI;XIA, YIFENG