| 发明名称 |
EXPRESSION SYSTEM FOR FACTOR VIII |
| 摘要 |
This invention describes a protein-free production process for proteins having factor VIII procoagulant activity. The process includes the derivation of stable human cell clones with high productivity for B-domain deleted Factor VIII, and (2) the adaptation of cells to grow in a medium free of plasma-derived proteins. |
| 申请公布号 |
EP1137797(B1) |
申请公布日期 |
2008.10.29 |
| 申请号 |
EP19990966068 |
申请日期 |
1999.12.08 |
| 申请人 |
BAYER CORPORATION |
发明人 |
CHO, MYUNG-SAM;CHAN, SHAM, YUEN;KELSEY, WILLIAM;YEE, HELENA |
| 分类号 |
C12N15/09;C12P21/06;A61K35/14;A61K38/00;A61P7/04;C07K1/00;C07K14/755;C12N5/10;C12N15/12;C12P21/02;C12P21/04;C12R1/91 |
主分类号 |
C12N15/09 |
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