摘要 |
The invention relates to an antibody, or antigen-binding fragment thereof, that binds specifically to a sclerostin polypeptide. The antibody or antigen-binding fragment is useful for increasing bone mineral content and/or bone mineral density in a warm-blooded animal or human, for example in the treatment of conditions such as osteopenia, osteoporosis, a fracture, achondroplasia, cleidrocranial dysostosis, echondromatosis, fibrous dysplasia, Gaucher's Disease, hypophoshatemic rickets, Marfan's syndrome, multiple hereditary exotoses, neurofibromatosis, osteogenesis inperfecta, osteopetrosis, osteopoikilosis, sclerotic lesions, peridontal disease, pseudoarthosis and pyogenic osteolmyelitis. |
申请人 |
CELLTECH R&D, INC. |
发明人 |
BRUNKOW, MARY E.;KOVACEVICH, BRIAN;PAEPER, BRYAN W.;WINKLER, DAVID G.;GALAS, DAVID J.;MULLIGAN, JOHN T.;VAN NESS, JEFFREY |