A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.
申请公布号
ZA200702965(B)
申请公布日期
2008.10.29
申请号
ZA20070002965
申请日期
2007.04.11
申请人
WARNER-LAMBERT COMPANY LLC.
发明人
DEBETTENCOURT III, ANTONE, JOHN;ROSE, PETER, ROBERT;SHALAEV, EVGENYI, YUR'EVICH;QUALLICH, GEORGE, JOSEPH;ZIEGLER, CARL, BERNARD