发明名称 |
Revascularization of ischemic retinal tissue and screening method thereof |
摘要 |
The present invention provides a treatment for promoting beneficial physiological revascularization of ischemic retinal tissue. The treatment comprises administering to a mammal suffering from a retinal vascular ischemia a therapeutically effective amount of an angiostatic fragment of tryptophanyl-tRNA synthetase (TrpRS), thereby simultaneously inhibiting pathological neovascularization while promoting beneficial physiological revascularization of damaged areas of the retina. In a preferred embodiment, the angiostatic fragment of TrpRS is T2-TrpRS or T2-TrpRS-GD. Preferably, the mammal is a human patient suffering from retinal ischemia. |
申请公布号 |
ZA200707134(B) |
申请公布日期 |
2008.10.29 |
申请号 |
ZA20070007134 |
申请日期 |
2007.08.23 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
FRIEDLANDER, MARTIN;AGUILAR, EDITH;BANIN, EYAL |
分类号 |
A01N;A61K;G01N |
主分类号 |
A01N |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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