Antimicrobial agents

摘要

The invention provides a replaceable aromatic compound which is an inhibitor for tRNA synthetase and also can be used as anti-microorganism agent. The compound can be used for curing or preventing diseases caused or promoted by gram positive, gram negative, anaerobic bacteria or epiphyte organism, in particular to bacteria such as Staphylococci, Enterococci, Streptococci, Haemophilus, Moraxalla, Escherichia, Chlamydia, Rickettsiae, Mycoplasm, Legionella, Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus and Enterobactericeae, and epiphyte organism such as Aspergillus, Blastomyces, Candida, Coccidiodes, Cryptococcus, Epidermophyton, Hendersonula, Histoplasma, Microsporum, Paecilomyces, Paracoccidiodes, Pneumocystis, Trichophyton and Trichosporium. The invention also provides a method for preparing the compound, pharmaceutical compositions of the compound and a method for curing the microorganism infection.