Substituted indazoly(indoly)maleimide derivatives as kinase inhibitors

摘要

The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): R² is selected from the group consisting of -C_1-8alkyl-Z, -C_2-8alkenyl-Z and -C_2-8alkynyl-Z; wherein the -C_1-8alkyl-Z, -C_2-8alkenyl-Z and -C_2-8alkynyl-Z and Z is a 5 to 6 member aromatic monocyclic heteroaryl ring having from 2 to 4 heteroatoms. These compounds are useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.