Pyrrolidine and thiazolidine compounds

摘要

Compounds of formula (I): wherein: X₁ represents an atom or group selected from CR_4aR_4b, O, S(O)_q1 and NR₅, wherein R_4a, R_4b, q₁ and R₅ are as defined in the description, m₁ represents zero or an integer from 1 to 4 inclusive, m₂ represents an integer from 1 to 4 inclusive, n₁ and n₂, which may be identical or different, each represent an integer from 1 to 3 inclusive, R₁ represents hydrogen or a group selected from carboxy, alkoxycarbonyl, optionally substituted carbamoyl and optionally substituted alkyl, R₂ represents hydrogen or alkyl, Ak represents an optionally substituted alkylene chain, p represents zero, 1 or 2, R₃ represents hydrogen or cyano, X₂ and X₃, which may be identical or different, each represent either S(O)_q2, or CR_6aR_6b, wherein q₂, R_6a and R_6b are as defined in the description, its optical isomers, where they exist, and its addition salts with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful as DPP-IV inhibitors.