| 摘要 |
<p>The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3'- hydroxy analogs, 5 '-halo and/or alkoxy analogs, and various 4 '-and/or 6'- substituents that incorporate a cyclic amine moiety.</p> |
