| 摘要 |
The invention relates to an immunological adsorber for treating inflammations, in particular for eliminating complement factors, and, optionally, additional sepsis-mediators, such as, TNF and interleukins from body fluids. The invention also relates to a method for the production and use of said immunological adsorber. The aim of the invention is to develop a modular immunoadsorption system, in particular for extracorporal detoxification, which enables plasma and tissue levels, which are specific to the patient, to be reduced. The inventive immunological adsorber consists of organic or synthetic polymer support materials whereon polyclonal and monoclonal antibodies are connected which are oriented counter to the complement factor C3a and/or C5a. In a preferred embodiment, other antibodies which are oriented counter to the additional inflammation mediators, are connected to the support. In a particularly advantageous embodiment, the invention relates to an immunoadsorber provided with antibodies against C5a and IL6.
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