发明名称 |
METHODS AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES |
摘要 |
Disclosed are methods, kits, and compositions for fluorescent detection of single biomolecules, e.g. proteins, using highly sensitive fluorescent dyes and a flow cell with one interrogation space for irradiation by focused laser beam. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution. |
申请公布号 |
WO2008048371(A3) |
申请公布日期 |
2008.10.16 |
申请号 |
WO2007US08394 |
申请日期 |
2007.04.04 |
申请人 |
SINGULEX, INC.;GOIX, PHILIPPE;PUSKAS, ROBERT;TODD, JOHN;LIVINGSTON, RICHARD;HELD, DOUGLAS |
发明人 |
GOIX, PHILIPPE;PUSKAS, ROBERT;TODD, JOHN;LIVINGSTON, RICHARD;HELD, DOUGLAS |
分类号 |
G01N21/76;G01N21/64 |
主分类号 |
G01N21/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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