The present invention relates to novel radioactively labeled bioreducible tracers of Formula (I) useful for detecting hypoxic tumors or ischemic tiss ue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moi ety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography.
申请公布号
CA2683433(A1)
申请公布日期
2008.10.16
申请号
CA20082683433
申请日期
2008.04.04
申请人
SIEMENS MEDICAL SOLUTIONS USA, INC.
发明人
DUCLOS, BRIAN A.;COLLIER, THOMAS LEE;ZHAO, TIEMING;GANGADHARMATH, UMESH B.;LIANG, QIANWA;KOLB, HARTMUTH C;WALSH, JOSEPH C.;PADGETT, HENRY CLIFTON;KASI, DHANALAKSHMI;KARIMI, FARHAD;GAO, ZHIYONG
