USE OF SH2 STAT3/STAT1 PEPTIDOMIMETICES AS ANTICANCER DRUGS
摘要
The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function. Peptidomimetics of the invention display selective inhibition of specific STAT isoform homo-dimerization. The peptidomimetic probes of STAT1 function, described herein, provide the means to preferentially inhibit STAT1 over STAT3 through the exploration of the C-terminus.
申请公布号
WO2008070833(A3)
申请公布日期
2008.10.16
申请号
WO2007US86779
申请日期
2007.12.07
申请人
UNIVERSITY OF SOUTH FLORIDA;YALE UNIVERSITY;SEBTI, SAID, M.;HAMILTON, ANDREW, D.;TURKSON, JAMES;JOVE, RICHARD
发明人
SEBTI, SAID, M.;HAMILTON, ANDREW, D.;TURKSON, JAMES;JOVE, RICHARD