METHOD FOR ASYMMETRIC HYDROGENATION OF ALLYL AMINE

摘要

Disclosed is a method for producing an optically active form of a compound represented by the formula (I<SUB>0</SUB>) or a salt of the optically active form, which is characterized by subjecting a compound represented by the formula (II<SUB>0</SUB>) or a salt thereof to asymmetric hydrogenation in the presence of a rhodium-(optically active ferrocenyl phosphine) complex catalyst. (II<SUB>0</SUB>) wherein R<SUP>1</SUP> and R<SUP>2</SUP> independently represent a hydrogen atom or a hydrocarbon or heterocyclic group which may have a substituent, or R<SUP>1</SUP>, R<SUP>2</SUP> and a carbon atom adjacent to R<SUP>1</SUP> and R<SUP>2</SUP>may together form a spiro ring which may have a substituent; the dashed line means that R<SUP>1</SUP> and R<SUP>2</SUP> may together form a ring; X represents (CH<SUB>2</SUB>)<SUB>n</SUB> (wherein n represents an integer of 1 to 4), a nitrogen atom, an oxygen atom or a sulfur atom; the ring A<SUB>0</SUB> represents an unsaturated 6-membered ring which may have a substituent; and the ring B represents a 5- to 7-membered heterocyclic ring which may have a substituent. (I<SUB>0</SUB>) wherein * represents the asymmetric center; and other variables are as defined above.