发明名称 |
PHOTODYNAMISCHE THERAPIE ZUR BEHANDLUNG VON AUGENERKRANKUNGEN |
摘要 |
Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of the PDT method can be enhanced by combining the PDT with an anti-angiogenesis factor, for example, angiostatin or endostatin, or with an apoptosis-modulating factor. Furthermore, the selectivity and sensitivity of the PDT may be further enhanced by coupling a targeting moiety to the photosensitizer so as to target the photosensitizer to choroidal neovasculature. |
申请公布号 |
DE60135633(D1) |
申请公布日期 |
2008.10.16 |
申请号 |
DE2001635633 |
申请日期 |
2001.02.09 |
申请人 |
MASSACHUSETTS EYE & EAR INFIRMARY |
发明人 |
MILLER, JOAN W.;GRAGOUDAS, EVANGELOS S.;RENNO, REEM Z. |
分类号 |
A61F9/007;A61K41/00;A61D7/00;A61K31/197;A61K31/352;A61K31/409;A61K31/655;A61K38/00;A61K38/10;A61K38/48;A61K45/06;A61K47/48;A61N5/06;A61P27/02 |
主分类号 |
A61F9/007 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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