| 摘要 |
PROBLEM TO BE SOLVED: To promote a safer and more effective antiviral agent, and basic and applied research on highly pathogenic avian influenza, HPAI, and to establish a method for diagnosing abnormal production of a peptide hormone related to MSP under a situation that no vaccine nor drug having specific effectiveness against HPAI are practically used and an existing drug causes a serious side effect. SOLUTION: MSPL, MSPS and TMPRSS13 inhibitors belonging to mosaic serine protease, MSP; a screening method for the above inhibitor using the degree of decomposition or cleavage of a substrate caused by these enzymes as an index; an antivirus agent and a therapeutic agent for peptide hormone disorder having the inhibitor as an active ingredient; an activation agent for enhancing infection and propagation of an HPAI virus and enabling its mass production; a therapeutic agent for peptide hormone disorder having the above enzymes as an active ingredient; an agent for diagnosing a hormone disorder using the amount of genetic expression of the above enzymes as an index; and the like. COPYRIGHT: (C)2009,JPO&INPIT
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