发明名称 |
C1-INACTIVATOR INHIBITS TWO-CHAIN UROKINASE MUTANT AND LIMITS HEMOSTATIC BLEEDING DURING THROMOLYSIS |
摘要 |
Methods for reducing bleeding during fibrinolysis treatment and for inhibiting the enzymatic activity of a two-chain urokinase mutant are described. Exogenous Cl- inactivator is administered during fibrinolysis treatment with the pro-urokinase mutant polypeptide, M5. The Cl-inactivator inhibits the formation of two-chain M5 resulting in less hemostatic bleeding. |
申请公布号 |
WO2007149141(A3) |
申请公布日期 |
2008.10.16 |
申请号 |
WO2007US08140 |
申请日期 |
2007.04.04 |
申请人 |
THROMBOLYTIC SCIENCE, INC. |
发明人 |
GUREWICH, VICTOR;PANNELL, RALPH |
分类号 |
A61K38/49;A61K36/36;C07H21/04;C12N9/64;C12N9/72 |
主分类号 |
A61K38/49 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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