| 发明名称 |
Optimized CD5 antibodies and methods of using the same |
| 摘要 |
The present invention describes antibodies that target CD5, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcgammaR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.
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| 申请公布号 |
US2008254027(A1) |
申请公布日期 |
2008.10.16 |
| 申请号 |
US20070982231 |
申请日期 |
2007.10.31 |
| 申请人 |
BERNETT MATTHEW J;CHU SEUNG YUP;DESJARLAIS JOHN R;KARKI SHER BAHADUR;PONG ERIK WEIKING;ZHUKOVSKY EUGENE ALEXANDER |
发明人 |
BERNETT MATTHEW J.;CHU SEUNG YUP;DESJARLAIS JOHN R.;KARKI SHER BAHADUR;PONG ERIK WEIKING;ZHUKOVSKY EUGENE ALEXANDER |
| 分类号 |
A61K39/395;A61P35/02;C07H21/04;C07K16/28;C12N5/06 |
主分类号 |
A61K39/395 |
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