METHOD FOR PRODUCING SUGAR CHAIN-MODIFIED URINASTATIN

摘要

PROBLEM TO BE SOLVED: To provide a method for producing a sugar chain-modified ulinastatin by replacing a glycosaminoglycan sugar chain of the original ulinastatin with a different glycosaminoglycan sugar chain under a planned modification design.

SOLUTION: At least a part of the nonreducing terminal side of a glycosaminoglycan sugar chain of ulinastatin is isolated by hydrolyzing with an endo-type glycosidase and a glycosaminoglycan to form a donor is bonded in place of the isolated chain by a sugar transfer reaction.

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