发明名称 |
Anti-T Cell and Autoantigen Treatment of Autoimmune Disease |
摘要 |
The invention is directed to a new method for the treatment of new onset Type I diabetes in mammals or for the treatment of pre-Type I diabetic mammals where the method comprises administering (a) anti-T cell therapy to the mammal and administering (b) an autoantigen and optional mucosal antigen composition, wherein (a) and (b) are administered concurrently or sequentially Exemplified is a treatment using a mixture of anti-CD3 antibodies, a glutamic acid decarboxylase (GAD) autoantigen, and an immunoregulatory cytokine Canme GAD sequences are also disclosed.
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申请公布号 |
US2008253991(A1) |
申请公布日期 |
2008.10.16 |
申请号 |
US20060815359 |
申请日期 |
2006.02.06 |
申请人 |
JEVNIKAR ANTHONY;MA SHENGWU;AINLEY WILLIAM MICHAEL;MERLO DONALD JOSEPH;RUSSELL SEAN MICHAEL;ARMSTRONG JANNA M |
发明人 |
JEVNIKAR ANTHONY;MA SHENGWU;AINLEY WILLIAM MICHAEL;MERLO DONALD JOSEPH;RUSSELL SEAN MICHAEL;ARMSTRONG JANNA M. |
分类号 |
A61K45/00;A01H5/00;A61K38/00;A61K38/28;A61K39/395;A61P37/00;C07K14/00;C12N15/00;C12N15/11;G01N33/00 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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