MICROBIAL REDUCTION OF AN ACETOXYKETONE

摘要

The present invention relates to biocatalytic asymmetric reduction for th e preparation of 2-amino- [5-( l-hydroxy-2-hydroxy or halogen-ethyl) ] -pyra zine derivatives of the formula (formula I) wherein R is lower alkylcarbonyl or an amino protecting group and R1 is hydroxy or halogen. The compounds ar e key intermediates in the manufacture of a glucokinase activator.