| 摘要 |
Compounds of formula (I) are CRTH2 ligands, useful in the treatment of, f or example, asthma and COPD wherein: R1 is halogen or cyano; R2 is hydrogen or methyl; R3 and R4 are independently -OR6, C1-C6alkyl or C3-C6cycloalkyl, the latter two groups being optionally substituted by one or more halogen at oms; R5 is hydrogen or halogen; R6 is C1C6alkyl or C3-C6cycloalkyl, either o f which being optionally substituted by one or more halogen atoms; X is -CH2 -, -S-, or -O-; one of Y and Y1 is hydrogen and the other is OR6, -C(=O)R7, NR8SO2R6 or a heterocyclic group selected from those referred to in the spec ification; and R6, R7 and R8 are as defined in the specification.
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