CONTROLLED RELEASE FORMULATION OF COATED MICROPARTICLES

摘要

Controlled release compositions comprising microparticles which comprise a core and at least one coat, wherein the core comprises at least one active agent(s), optionally at least one water soluble polymer(s) and optionally one or more pharmaceutically acceptable excipient(s); and at least one coat comprising at least one pH independent polymer(s) along with one or more pharmaceutically acceptable excipient(s) are provided. Preferably the controlled release pharmaceutical compositions comprise microparticles along with at least one in-situ gelling agent(s), at least one cross-linking agent(s) and optionally one or more pharmaceutically acceptable excipient(s), wherein the said compositions are formulated as oral reconstitutable pharmaceutical controlled release suspensions, which can be reconstituted using a suitable reconstituting medium such as water. Further, this invention provides process of preparation of such compositions and method of using them.