发明名称 |
METHOD OF TREATING GLAUCOMA |
摘要 |
Provided herein are methods of protecting all or a portion of the optic nerve fiber layer within the optic nerve/lamina cribrosa (ONLC) complex in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's peripapillary sclera, thereby stiffening the individual's peripapillary sclera and protecting all or a portion of the optic nerve fiber layer within the ONLC of the individual. In a particular embodiment, the invention is directed to methods of treating glaucoma in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's peripapillary sclera, thereby stiffening the individual's peripapillary sclera and treating the glaucoma in the individual. In yet another embodiment, the invention is directed to methods of treating glaucomatous optic neuropathy in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's peripapillary sclera, thereby stiffening the individual's peripapillary sclera and treating the glaucomatous optic neuropathy in the individual. The method can further comprise administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's lamina cribrosa (LC). |
申请公布号 |
WO2008124009(A2) |
申请公布日期 |
2008.10.16 |
申请号 |
WO2008US04299 |
申请日期 |
2008.04.02 |
申请人 |
THE CLEVELAND CLINIC FOUNDATION;KRUEGER, RONALD, R.;DUPPS, WILLIAM, J.;TROKEL, STEVEN;THORNTON, IVEY |
发明人 |
KRUEGER, RONALD, R.;DUPPS, WILLIAM, J.;TROKEL, STEVEN;THORNTON, IVEY |
分类号 |
A61P27/06;A61K31/11;A61K31/525;A61K31/70;A61K33/00;A61K45/00 |
主分类号 |
A61P27/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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