METHOD FOR INHIBITION OF SIGNALING THROUGH ErbB2, SIGNALING INHIBITOR FOR USE IN THE METHOD, AND USE OF THE SIGNALING INHIBITOR

摘要

Disclosed is a method for inhibiting the activation of a signaling pathway through ErbB2 in a human cell. Also disclosed is a signaling inhibitor for use in the method. Specifically disclosed is a polypeptide comprising at least one of PTB domain and ERK2 binding domain in human FRS2ß. The polypeptide can inhibit the activation of the signaling pathway. The polypeptide in itself may be introduced into a cell. Alternatively, a nucleic acid encoding the polypeptide may be introduced into a cell where the polypeptide may be expressed. The polypeptide or the nucleic acid can be used as a signaling inhibitor or the like. The signaling inhibitor is useful as an anti-cancer agent or the like, because ErbB2 is involved in the development of cancer.