GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO

摘要

GnRH receptor antagonists are disclosed which have utility in the treatme nt of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure, wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solv ates and pharmaceutically acceptable salts thereof. Also disclosed are compo sitions containing a compound of this invention in combination with a pharma ceutically acceptable carrier, as well as methods relating to the use thereo f for antagonizing gonadotropin-releasing hormone in a subject in need there of.