DELTA-9 ELONGASES AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS

摘要

The present invention relates to Delta9 elongases, which have the ability to convert linoleic acid (LA; 18:2 omega-6) to eicosadienoic acid (EDA; 20:2 omega-6) and/or alpha-linolenic acid (ALA; 18:3 omega-3) to eicosatrienoic acid (ETrA; 20:3 omega-3). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Delta9 elongases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these Delta9 elongases in oleaginous yeast are disclosed.