发明名称 |
FUSION PROTEIN OF COLLAGEN-BINDING DOMAIN AND PARATHYROID HORMONE |
摘要 |
Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented. |
申请公布号 |
CA2930681(A1) |
申请公布日期 |
2008.10.16 |
申请号 |
CA20082930681 |
申请日期 |
2008.04.09 |
申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS;NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY;OCHSNER CLINIC FOUNDATION |
发明人 |
MATSUSHITA, OSAMU;GENSURE, ROBERT C.;SAKON, JOSHUA;PONNAPAKKAM, TULASI |
分类号 |
A61K47/48;A61P19/08;A61P35/04 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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