PROCESS FOR PREPARING NEW ALKANOLAMINE DERIVATIVES

摘要

1471431 Alkanolamine derivatives SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 30 April 1975 [30 April 1974] 18838/74 Heading C2C Novel compounds of Formula I wherein n is 2 or 3, R 1 and R 2 , which are the same or different, each represent an alkyl radical having from 1 to 4 carbon atoms, in a straight or branched chain, or R 1 and R 2 , taken together with the nitrogen atom to which they are bonded, represent a pyrrolidinyl, piperidino, dimethylpiperidino, morpholino, 1-thiomorpholino, azabicyclo[3,3,0]octyl or azabicyclo[3,2,2]- nonyl radical and acid addition salts thereof are prepared either by reaction of a compound of Formula V with a compound of Formula III or by hydrogenation of a compound of formula IV Intermediates of Formula IV above are prepared by reaction of a compound of Formula III above with a compound of Formula II dl - 1 - (3 - Trifluoromethylphenyl) - 2 - benzylaminopropane is resolved via salts with l-eamphosulphate and d-dibenzoyltartrate. Esters of acids of Formula II above are resolved in conventional manner and converted to the free acids. Pharmaceutical compositions in conventional forms for oral, rectal or parenteral administration and having anorectic and lipid regulating activity comprise an above novel compound and a carrier or diluent.