| 摘要 |
The present invention provides an isolated HIV-1 mutant and isolated nucl eic acid molecules comprising HIV-RT coding sequences harboring a novel muta tion in the S68 codon, and in particular, deletions of the S68 codon. This n ovel deletion reduces the sensitivity of HIV to various nucleoside reverse t ranscriptase inhibitors. Methods of using this mutation for selecting effect ive antiretroviral agents in vitro and in vivo, methods for monitoring infec tion progression in HIV-infected individuals and methods for avoiding the em ergence of and/or to treat individuals infected with HIV comprising mutation s at the S68 codon of HIV-RT, e.g., S68del, are provided. |
