VERFAHREN ZUR IDENTIFIKATION VON ANTIVIRALE SUBSTANZEN

摘要

The invention is concerned among other with means and method for determining whether a compound influences a phase in the life cycle of a virus. The invention utilizes the striking observation that cells comprising a nucleic acid encoding an adenovirus early protein or a functional part, derivative and/or analogue of said adenovirus early protein are capable of replicating a wide variety of viruses and thus support all the life cycle steps of these viruses. Even viruses that are difficult to grow on other cells are replicated by such cells. The cells are therefore particularly well suited for the screening, selection, isolation or testing of compounds that influence a step in the life cycle of said virus. The invention further provides compounds obtainable by a method of the invention.