摘要 |
A compound represented by general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their medical applications. Since these compounds inhibit the action of chemokines such as MIP-1.alpha. and/or MCP-1 on target cells, they may be useful as a therapeutic drug and/or preventative drug in diseases, such as atherosclerosis, rheumatoid arthritis, and the like where blood monocytes and lymphocytes infiltrate into tissues.
|
申请人 |
TEIJIN LIMITED;DUPONT PHARMACEUTICALS RESEARCH LABORATORIES |
发明人 |
TARBY, CHRISTINE M.;TEIG, STEVEN L.;SUDOH, MASAKI;TAKENOUCHI, OSAMI;SOGAWA, RYO;TSUTSUMI, TAKAHARU;MORITA, TAKUYA;MOREE, WILNA;IMAI, MINORU;SHIOTA, TATSUKI;KATAOKA, KEN-ICHIRO;HADA, TAKAHIKO;MUROGA, YUMIKO;ENDO, NORIAKI;FURUYA, MINORU |