摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention concerns C1-symmetrical biophosphine ligands and respective catalysts and their application in asymmetrical syntheses, including enantioselective hydration of prochiral olefins for production of pharmaceutical compounds, including (S)-(+)-3-(aminomethyl)-5-methylhexane acid known as pregabaline and its structurally related compounds. The methods involve new prochiral catalysts or precatalysts for obtaining the catalysts, including chiral ligand, connected to rhodium by phosphor atoms, with chiral ligand structure represented by the formula 4 . ^ EFFECT: obtaining new catalysts for application in asymmetrical syntheses. ^ 19 cl, 46 ex, 7 tbl,7 dwg |