| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention concerns improved method of obtaining mevalonic acid derivatives of the general formula I or its pharmaceutically acceptable salt with base, or lactone, where -CH2-CH2- or -CH=CH-, R is heterocyclical residual of interaction of compound of the general formula IIa , where R1, R2, R3, R4 meanings are described in the invention, with compound of the general formula IIb: R-CH(=O) where R is cyclical residual. Obtained compound is recovered in the presence of recovery agent, preferably a compound of the formula IId , where M is Ru, Rh, Ir, Fe, Co, Ni, L1 - H, L2 - aryl, R5 is aliphatic residual, R8 and R9 are C6H5 or form cyclohexane ring or cyclohexane or cyclopentane ring combined with C atom, to which they are bound, with a number of further stages. ^ EFFECT: high product output. ^ 4 cl, 1 ex
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