COMPOSITION OF CATIONIC PHOSPHOLIPID NANOPARTICLES FOR EFFECTIVE DELIVERY OF NUCLEIC ACIDS

摘要

The present invention provides a cationic phospholipid liposome composition comprising l,2-dioleoyl-sn-glycero-S-ethylphosphocholine (EDOPC), 3ß-[N-(N',N'- dimethylaminoethane)-carbamoyl] cholesterol (DC-cholesterol) and 1,2-diphytanoyl-sn- glycero-3-phosphoethanolamine (DPhPE), a liposome-nucleic acid complex which is capable of forming a complex therewith, and a pharmaceutical composition comprising the same. The cationic phospholipid liposome of the present invention is highly effective for intracellular delivery of nucleic acids and reduction of cytotoxicity, as compared to conventional liposome products. Therefore, the present invention can be useful for gene therapy via intracellular delivery of a desired material to target cells.